Advances in pH-Sensitive Polymers for Smart Insulin Delivery

Smart polymers for responsive drug-delivery systems.

The rapid advancement of biomedical research has led to many creative applications for biocompatible polymers. As modern medicine discerns more mechanisms, both of physiology and of pathophysiology, the approach to healing is to mimic, or if possible, to recreate the physiology of healthy functioning. Thus, the area of smart polymers for responsive drug delivery has evolved. The developments fa...

In vitro In vivo comparison of two pH sensitive Eudragit polymers for colon specific drug delivery

The aim of this study was to develop the polymer coated diclofenac tablet containing superdisintegrant for colonic drug delivery and compare the in vivo performance of two polymers for site specificity. Eudragit FS 3D and Eudragit S100 were used as pH sensitive polymers. Tablets were prepared to give fast release at specific site with the help of sodium starch glycolate as superdisintegrant. Ta...

Smart Polymers in Nasal Drug Delivery

Nasal drug delivery has now been recognized as a promising route for drug delivery due to its capability of transporting a drug to systemic circulation and central nervous system. Though nasal mucosa offers improved bioavailability and quick onset of action of the drug, main disadvantage associated with nasal drug delivery is mucocilliary clearance due to which drug particles get cleared from t...

pH-Sensitive Mebeverine Microspheres for Colon Delivery

Mebeverine hydrochloride is known to suffer from extensive first pass effect. In an attempt to improve its oral bioavailability and possibility to restrict its absorption only to the colon, mebeverine microspheres were prepared by emulsion solvent evaporation method. Four formulations were prepared with varying drug and polymer ratio. These formulations were subjected to various evaluation para...

Advances in Targeted Drug Delivery